BS

VASH1

Vazohibin-1 je protein koji je kod ljudikodirangenVASH1.[5]

VASH1
Identifikatori
Aliasi VASH1
Vanjski ID-jevi OMIM: 609011MGI: 2442543HomoloGene: 8941GeneCards: VASH1
Lokacija gena (čovjek)
Hrom. Hromosom 14 (čovjek)[1]

Bend 14q24.3 Početak 76,761,468 bp[1]
Kraj 76,783,015 bp[1]
Lokacija gena (miš)
Hrom. Hromosom 12 (miš)[2]

Bend 12|12 D2 Početak 86,678,700 bp[2]
Kraj 86,692,091 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948 protein binding
actin binding
metallocarboxypeptidase activity
carboxypeptidase activity
peptidase activity
hydrolase activity
Ćelijska komponenta citoplazma
extracellular region
apical part of cell
Endoplazmatski retikulum
Vanćelijsko
Biološki proces negative regulation of angiogenesis
regulation of cellular senescence
Ćelijski ciklus
negative regulation of lymphangiogenesis
response to wounding
regulation of angiogenesis
negative regulation of blood vessel endothelial cell migration
Angiogeneza
negative regulation of endothelial cell migration
negative regulation of endothelial cell proliferation
placenta blood vessel development
labyrinthine layer blood vessel development
Proteoliza
Izvori:Amigo / QuickGO
Ortolozi
Vrste Čovjek Miš
Entrez

22846

238328

Ensembl

ENSG00000071246

ENSMUSG00000021256

UniProt

Q7L8A9

Q8C1W1

RefSeq (mRNK)

NM_014909

NM_177354

RefSeq (bjelančevina)

NP_055724

NP_796328

Lokacija (UCSC) Chr 14: 76.76 – 76.78 Mb Chr 12: 86.68 – 86.69 Mb
PubMed pretraga [3] [4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Gross (2018) mapirao je gen VASH1 u hromosomu 14, sekvenca 14q24.3, na osnovu poravnavanja sekvence VASH1 (GenBank BC009031) sa genomskom sekvencom (GRCh38).[6] VASH1 je inhibitor angiogeneze koji proizvode i izlučuju vaskularne endotelne ćelije (EC), nakon stimulacije VEGF-om (VEGFA) i FGF2 (Suzuki et al., 2010

. . . VASH1 . . .

Dužina polipeptidnog lanca je 365 aminokiselina, a molekulska težina 40.957 Da.[7]

10 20 30 40 50
MPGGKKVAGG GSSGATPTSA AATAPSGVRR LETSEGTSAQ RDEEPEEEGE
EDLRDGGVPF FVNRGGLPVD EATWERMWKH VAKIHPDGEK VAQRIRGATD
LPKIPIPSVP TFQPSTPVPE RLEAVQRYIR ELQYNHTGTQ FFEIKKSRPL
TGLMDLAKEM TKEALPIKCL EAVILGIYLT NSMPTLERFP ISFKTYFSGN
YFRHIVLGVN FAGRYGALGM SRREDLMYKP PAFRTLSELV LDFEAAYGRC
WHVLKKVKLG QSVSHDPHSV EQIEWKHSVL DVERLGRDDF RKELERHARD
MRLKIGKGTG PPSPTKDRKK DVSSPQRAQS SPHRRNSRSE RRPSGDKKTS
EPKAMPDLNG YQIRV
Simboli

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